CBD 101

CBD Oil Simply green organics: What are 7 Proven or Possible Health Benefits?

Benefits of CBD

The CBD business is expected to generate over $20 billion in sales by 2024.1 But what precisely is CBD product and how effective is it? We look at 7 health benefits of CBD oil that have been demonstrated or may be potential.

What exactly is CBD?

CBD (short for cannabidiol) is one of more than 200 chemical components present in cannabis known as cannabinoids. It is the second most common active ingredient identified in cannabis, after THC (tetrahydrocannabinol), which is the psychoactive compound in cannabis that gives individuals a high.2

Cannabis is a plant that comes in two different varieties: Cannabis Indica and Cannabis Sativa. Cannabis and CBD can come from either variety, however hemp can only come from Cannabis Sativa. To be considered hemp, hemp must have less than 0.3 percent THC (the psychoactive ingredient in marijuana). Otherwise, growers risk being prosecuted under federal law. Clothing, packaging, biofuel, building materials, and paper can all be made from hemp, which is 100 percent biodegradable and environmentally beneficial.

CBD derived from hemp contains less than 0.3 percent THC and is legal in the United States, however it is still banned in several states. CBD products produced from cannabis, on the other hand, are banned on the federal level but permitted in some states.

CBD, unlike THC, does not have psychoactive effects and does not provide a “high.” According to the World Health Organization, there is no evidence that it has any potential for misuse or dependency, and there is no evidence that it is linked to any major negative effects.

CBD has been linked to the relief of a variety of medical ailments, including epilepsy, anxiety, inflammation, sleeplessness, and pain. Despite the fact that “credited” does not imply “proven.” Due to the previous regulatory context, there are few well-conducted trials to back up such claims, however research is likely to go up now that hemp and marijuana are legally differentiated.

We take a look at nine medical illnesses where CBD may be beneficial or has already been demonstrated to be so.

  1. Epilepsy

Epidiolex (a plant-based formulation of CBD) was approved by the FDA in June 2018 to treat seizures in patients aged 2 and above who have Dravet syndrome or Lennox-Gastaut syndrome (LGS), two uncommon forms of epilepsy.

CBD has also been studied for use in various types of treatment-resistant epilepsy, typically in conjunction with standard epileptic drugs. The results varied, but several studies found that CBD reduced seizure frequency by over 44% in the majority of people.3

CBD interacts with other epileptic drugs, and certain serious side effects have been documented, including a reduction in liver function in those who are also taking valproate.

CBD is effective in the treatment of certain kinds of epilepsy.

  1. Pain

CBD has been proven in animal experiments to have anti-inflammatory properties and to reduce pain by acting on the endocannabinoid and pain-sensing systems.

Unfortunately, there are few human trials evaluating the efficacy of CBD as a single agent to reduce pain, with the majority of research combining CBD and THC to alleviate pain. Notably, Health Canada has approved a combination drug containing both THC and CBD in a 1:1 ratio for the management of central nerve-related pain in multiple sclerosis, as well as cancer pain that has not responded to optimal opioid therapy.

There was a statistically significant improvement in self-reported quality of life measures for those with non-cancer-related pain in an observational study of CBD treatment, but no statistically significant improvement in those with cancer-related pain or neurological symptoms.8

A case study of 47 persons with multiple sclerosis found that combining CBD and THC improved pain, walking, and muscle spasms. 15

CBD has been proven in animal tests to have a favourable effect on serotonin levels in the brain and serotonin. Serotonin deficiency is hypothesised to play a function in both mood and pain.11

CBD has anti-inflammatory properties, according to other research (both animal and human), and it may reduce pain through this mechanism.

CBD may interfere with other medications used to treat heart issues or immunosuppressants, so consult your doctor before using it.

Conclusion: CBD may help with pain relief, but there are no high-quality human trials to back this up.

  1. CBD for healthy lifestleArthritis

Topical CBD treatments reduce pain and inflammation linked with arthritis in animals with few adverse effects, according to animal research. CBD is best applied topically because it is poorly absorbed when taken orally and can produce gastrointestinal side effects. 6

Conclusion: Topical CBD may be helpful in the treatment of arthritis, however there are no high-quality human studies to back this up.

  1. Anxiety

In 57 healthy guys who performed a simulated public speaking test, pretreatment with 300mg CBD dramatically reduced anxiety. However, the men’s anxiety levels were unaffected by dosages of 150mg CBD and 600mg CBD.7

An observational study found that CBD had beneficial effects on anxiety in 21 patients out of 400 who had anxiety.

In a large case series of 72 patients, anxiety levels dropped, with 57 patients (79.2%) reporting lower scores during the first month of CBD treatment. 9

Conclusion: CBD may help with anxiety before activities such as public speaking, however the best dose is unknown.

  1. Depression

CBD has been found in animal experiments to help with depression, which could be due to its powerful anti-stress effect after either acute or recurrent administration.16

CBD has been proven in animal tests to have a favourable effect on serotonin levels in the brain and serotonin. Serotonin deficiency is hypothesised to play a function in both mood and pain.11

Conclusion: CBD may be helpful in the treatment of depression, but additional research is needed.

  1. Sleep disturbances

CBD improved sleep for 31% of patients using it for diseases other than cancer, such as anxiety or non-cancer pain.

In a large case series of 72 patients, 48 (66.7 percent) reported an improvement in sleep ratings within the first month, however these scores changed throughout time.9

CBD appeared to sustain sleep architecture in other trials using 300 mg of CBD in persons with anxiety or depression, indicating that it was unlikely to have any deleterious effects on sleep quality.10

 

Conclusion: CBD appears to have no effect on sleep and may even help people sleep better.

  1. Acne

CBD inhibited the production of excessive sebum by human sebocytes, as well as having an anti-inflammatory impact that prevented the activation of inflammatory cytokines, according to a laboratory study. Because acne is characterised by excessive sebum and irritation, topical CBD may be an effective treatment for acne and may prevent or minimise future breakouts.12,13

Conclusion: Topical CBD may help reduce acne-related inflammation and excessive sebum production, but additional research is needed.

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